Cancer Immunotherapy : Blazing the Trail with Melanoma

Interfering with the immune system in order to eliminate cancer cells was one of the most attractive and exciting goals in oncology. After decades of deceived efforts and disappointing clinical trials, this long lasting objective was finally reached in 2011 with the authorization of a new immunotherapy in patients suffering from metastatic melanoma, which is one of the most challenging situation in oncology. This innovative treatment, based on the blockade of a physiological brake of the immune system, was the first specimen of a new generation of drugs called checkpoint inhibitors that are now developed in various tumor types. Along with this new concept, profound re-evaluations of assessing the efficacy of the drugs, managing the new toxicity profiles and addressing the patient’s quality of life are emerging leading to a global revolution the field of cancer treatment. 

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